.Pharmacolibrary.Drugs.G_GenitoUrinarySystemAndSexHormones.G01A_AntiinfectivesAndAntisepticsExclCombinationsWith.G01AX02_Inosine.Inosine

Information

name:Inosine
ATC code:G01AX02
route:oral
n-compartments1

Inosine is a purine nucleoside formed by the deamination of adenosine. It has been used as a medication for various conditions, such as immunomodulation or neuroprotection, but it is not widely approved or in common use today. Its utility in clinical practice is limited and not supported by major regulatory agencies.

Pharmacokinetics

No published pharmacokinetic data are available for inosine in humans; the following parameters are estimates based on its structural similarity to adenosine and other nucleosides, as well as general pharmacokinetic principles.

References

  1. Staatz, CE, & Tett, SE (2007). Clinical pharmacokinetics and pharmacodynamics of mycophenolate in solid organ transplant recipients. Clinical pharmacokinetics 46(1) 13–58. DOI:10.2165/00003088-200746010-00002 PUBMED:https://pubmed.ncbi.nlm.nih.gov/17201457

  2. Li, H, et al., & McCune, JS (2014). Pharmacokinetic and pharmacodynamic analysis of inosine monophosphate dehydrogenase activity in hematopoietic cell transplantation recipients treated with mycophenolate mofetil. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 20(8) 1121–1129. DOI:10.1016/j.bbmt.2014.03.032 PUBMED:https://pubmed.ncbi.nlm.nih.gov/24727337

  3. McHutchison, JG, et al., & Alam, J (2005). A randomized, double-blind, placebo-controlled dose-escalation trial of merimepodib (VX-497) and interferon-alpha in previously untreated patients with chronic hepatitis C. Antiviral therapy 10(5) 635–643. PUBMED:https://pubmed.ncbi.nlm.nih.gov/16152757

Revisions


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