name: | Ibuprofen_1 |
ATC code: | G02CC01_1 | route: | intravenous |
n-compartments | 2 |
Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) used for the treatment of pain, fever, and inflammation. It is approved and commonly used worldwide for mild to moderate pain, dysmenorrhea, and inflammatory conditions such as arthritis.
Pharmacokinetic parameters reported for healthy adult volunteers after single intravenous administration.
Jin, Y, et al., & Wang, Z (2023). Comparison of intravenous ibuprofen pharmacokinetics between Caucasian and Chinese populations using physiologically based pharmacokinetics modeling and simulation. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 191 106587–None. DOI:10.1016/j.ejps.2023.106587 PUBMED:https://pubmed.ncbi.nlm.nih.gov/37734467
Zhou, H, et al., & Liu, Y (2016). Pharmacokinetics and tolerability of intravenous ibuprofen injection in healthy Chinese volunteers: a randomized, open-label, single- and multiple-dose study . International journal of clinical pharmacology and therapeutics 54(11) 904–913. DOI:10.5414/CP202603 PUBMED:https://pubmed.ncbi.nlm.nih.gov/27569737
Han, EE, et al., & Shapiro, BJ (2004). Pharmacokinetics of Ibuprofen in children with cystic fibrosis. Clinical pharmacokinetics 43(3) 145–156. DOI:10.2165/00003088-200443030-00001 PUBMED:https://pubmed.ncbi.nlm.nih.gov/14871154