.Pharmacolibrary.Drugs.G_GenitoUrinarySystemAndSexHormones.G02C_OtherGynecologicals.G02CX01_Atosiban.Atosiban

Information

Atosiban is an oxytocin receptor antagonist used as a tocolytic agent, meaning it is used to suppress premature labor. It is approved in many countries in Europe, but not in the United States.

Pharmacokinetics

Pharmacokinetic parameters reported in healthy female volunteers and pregnant women between 24 and 33 weeks of gestation undergoing preterm labor, following intravenous administration.

References

1. Goodwin, TM, et al., & Holland, ML (1995). The pharmacokinetics of the oxytocin antagonist atosiban in pregnant women with preterm uterine contractions. American journal of obstetrics and gynecology 173(3 Pt 1) 913–917. DOI:10.1016/0002-9378(95)90365-8 PUBMED:https://pubmed.ncbi.nlm.nih.gov/7573268

2. Rasmussen, BB, et al., & Senderovitz, T (2005). Pharmacokinetic interaction studies of atosiban with labetalol or betamethasone in healthy female volunteers. BJOG : an international journal of obstetrics and gynaecology 112(11) 1492–1499. DOI:10.1111/j.1471-0528.2005.00735.x PUBMED:https://pubmed.ncbi.nlm.nih.gov/16225568

Revisions

• 06/2025 initial generated model