.Pharmacolibrary.Drugs.G_GenitoUrinarySystemAndSexHormones.G03A_HormonalContraceptivesForSystemicUse.G03AA08_MedroxyprogesteroneAndEthinylest.MedroxyprogesteroneAndEthinylest .Pharmacolibrary.Drugs.G_GenitoUrinarySystemAndSexHormones.G03A_HormonalContraceptivesForSystemicUse.G03AA08_MedroxyprogesteroneAndEthinylest.MedroxyprogesteroneAndEthinylest| name: | MedroxyprogesteroneAndEthinylestradiol |
| ATC code: | G03AA08 | route: | oral |
| n-compartments | 1 |
Medroxyprogesterone and ethinylestradiol is a combined oral contraceptive containing the progestin medroxyprogesterone acetate and the estrogen ethinylestradiol. This combination was previously used for hormonal contraception and regulation of menstrual disorders. Currently, it is not widely used or approved in most countries, having been largely replaced by other contraceptive combinations.
Estimated pharmacokinetic parameters for healthy adult women based on published pharmacokinetics of individual components (medroxyprogesterone acetate and ethinylestradiol) as no specific studies of the combination were identified.
Mohamed, MF, et al., & Othman, AA (2019). The JAK1 Inhibitor Upadacitinib Has No Effect on the Pharmacokinetics of Levonorgestrel and Ethinylestradiol: A Study in Healthy Female Subjects. Journal of clinical pharmacology 59(4) 510–516. DOI:10.1002/jcph.1350 PUBMED:https://pubmed.ncbi.nlm.nih.gov/30500075
Darwish, M, et al., & Grasela, T (2014). A comparison of the pharmacokinetic profile of an ascending-dose, extended-regimen combined oral contraceptive to those of other extended regimens. Reproductive sciences (Thousand Oaks, Calif.) 21(11) 1401–1410. DOI:10.1177/1933719114526472 PUBMED:https://pubmed.ncbi.nlm.nih.gov/24647707