.Pharmacolibrary.Drugs.G_GenitoUrinarySystemAndSexHormones.G03A_HormonalContraceptivesForSystemicUse.G03AC03_Levonorgestrel.Levonorgestrel

Information

name:Levonorgestrel
ATC code:G03AC03
route:oral
n-compartments2

Levonorgestrel is a synthetic progestogen used primarily as an emergency contraceptive and as an active component in various hormonal contraceptive regimens, including oral contraceptives, intrauterine devices (IUDs), and subdermal implants. It is approved by regulatory agencies such as the FDA and is widely used today for both prevention of pregnancy after unprotected intercourse and for long-term contraception.

Pharmacokinetics

Healthy adult women, single oral dose, fasting state.

References

  1. Reinecke, I, et al., & Garmann, D (2018). An Integrated Population Pharmacokinetic Analysis to Characterize Levonorgestrel Pharmacokinetics After Different Administration Routes. Journal of clinical pharmacology 58(12) 1639–1654. DOI:10.1002/jcph.1288 PUBMED:https://pubmed.ncbi.nlm.nih.gov/30207604

  2. Kuhnz, W (1990). Pharmacokinetics of the contraceptive steroids levonorgestrel and gestodene after single and multiple oral administration to women. American journal of obstetrics and gynecology 163(6 Pt 2) 2120–2127. DOI:10.1016/0002-9378(90)90551-h PUBMED:https://pubmed.ncbi.nlm.nih.gov/2124087

  3. Adedoyin, A, et al., & Iwamoto, M (2019). Effect of letermovir on levonorgestrel and ethinyl estradiol pharmacokinetics
. International journal of clinical pharmacology and therapeutics 57(9) 450–457. DOI:10.5414/CP203483 PUBMED:https://pubmed.ncbi.nlm.nih.gov/31232280

Revisions


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