.Pharmacolibrary.Drugs.G_GenitoUrinarySystemAndSexHormones.G03A_HormonalContraceptivesForSystemicUse.G03AC06_Medroxyprogesterone.Medroxyprogesterone

Information

Medroxyprogesterone is a synthetic progestin, a derivative of progesterone, used in hormone replacement therapy, treatment of endometriosis, amenorrhea, abnormal uterine bleeding, and as a component of contraceptive injections (medroxyprogesterone acetate). It is an FDA-approved medication, widely used both for contraception (as depot medroxyprogesterone acetate, DMPA) and for other gynecological indications.

Pharmacokinetics

Pharmacokinetic parameters in healthy adult women after a single intramuscular injection of depot medroxyprogesterone acetate (DMPA).

References

1. Zhou, XF, et al., & Sang, GW (1998). Pharmacokinetics of medroxyprogesterone acetate after single and multiple injection of Cyclofem in Chinese women. Contraception 57(6) 405–411. DOI:10.1016/s0010-7824(98)00048-1 PUBMED:https://pubmed.ncbi.nlm.nih.gov/9693401

2. Zahradnik, HP (1995). [Depot gestagens]. Archives of gynecology and obstetrics 257(1-4) 536–541. DOI:10.1007/BF02264884 PUBMED:https://pubmed.ncbi.nlm.nih.gov/8579439

3. Longo, N, et al., & Sile, S (2014). Single-dose, subcutaneous recombinant phenylalanine ammonia lyase conjugated with polyethylene glycol in adult patients with phenylketonuria: an open-label, multicentre, phase 1 dose-escalation trial. Lancet (London, England) 384(9937) 37–44. DOI:10.1016/S0140-6736(13)61841-3 PUBMED:https://pubmed.ncbi.nlm.nih.gov/24743000

Revisions

• 06/2025 initial generated model