.Pharmacolibrary.Drugs.G_GenitoUrinarySystemAndSexHormones.G03B_Androgens.G03BA03_Testosterone.Testosterone

Information

Testosterone is a naturally occurring steroid hormone that plays a key role in the development of male reproductive tissues and secondary sexual characteristics. It is used clinically for testosterone replacement therapy in males with hypogonadism and in certain other endocrine disorders. Testosterone is an approved drug for therapeutic use in many countries.

Pharmacokinetics

Pharmacokinetic parameters reported for healthy adult males following single intramuscular injection of testosterone enanthate.

References

1. Pastuszak, AW, et al., & Hu, Y (2021). Population Pharmacokinetic Modeling and Simulations to Evaluate a Potential Dose Regimen of Testosterone Undecanoate in Hypogonadal Males. Journal of clinical pharmacology 61(12) 1618–1625. DOI:10.1002/jcph.1939 PUBMED:https://pubmed.ncbi.nlm.nih.gov/34269421

2. Vogiatzi, MG, et al., & Rogol, AD (2023). Allometric Scaling of Testosterone Enanthate Pharmacokinetics to Adolescent Hypogonadal Males (IM and SC Administration). Journal of the Endocrine Society 7(6) bvad059–None. DOI:10.1210/jendso/bvad059 PUBMED:https://pubmed.ncbi.nlm.nih.gov/37180212

3. Chioma, L, & Cappa, M (2023). Hypogonadism in Male Infants and Adolescents: New Androgen Formulations. Hormone research in paediatrics 96(6) 581–589. DOI:10.1159/000521455 PUBMED:https://pubmed.ncbi.nlm.nih.gov/34915486

Revisions

• 06/2025 initial generated model