.Pharmacolibrary.Drugs.G_GenitoUrinarySystemAndSexHormones.G03C_Estrogens.G03CA03_Estradiol.Estradiol

Information

Estradiol is a potent estrogen steroid hormone involved in the development and maintenance of female reproductive tissues and secondary sexual characteristics. It is widely used as hormone replacement therapy in menopausal women, in contraception, and in transgender hormone therapy. Estradiol is approved and in clinical use today in various formulations.

Pharmacokinetics

Pharmacokinetic parameters reported for healthy adult female volunteers aged 18-35 after a single oral dose of micronized estradiol.

References

1. Doll, E, et al., & Sarvaideo, JL (2022). Pharmacokinetics of Sublingual Versus Oral Estradiol in Transgender Women. Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists 28(3) 237–242. DOI:10.1016/j.eprac.2021.11.081 PUBMED:https://pubmed.ncbi.nlm.nih.gov/34781041

2. Zhang, L, et al., & Shentu, J (2024). Pharmacokinetics and Safety of Estradiol Valerate Tablet and Its Generic: A Phase 1 Bioequivalence Study in Healthy Chinese Postmenopausal Female Subjects. Drug design, development and therapy 18 2891–2904. DOI:10.2147/DDDT.S460681 PUBMED:https://pubmed.ncbi.nlm.nih.gov/39006193

3. Luo, D, et al., & Jusko, WJ (2019). Altered pharmacokinetics of combined oral contraceptives in obesity - multistudy assessment. Contraception 99(4) 256–263. DOI:10.1016/j.contraception.2018.12.009 PUBMED:https://pubmed.ncbi.nlm.nih.gov/30684471

Revisions

• 06/2025 initial generated model