.Pharmacolibrary.Drugs.G_GenitoUrinarySystemAndSexHormones.G03C_Estrogens.G03CX01_Tibolone.Tibolone

Information

Tibolone is a synthetic steroid used primarily in hormone replacement therapy (HRT) for postmenopausal women to relieve menopausal symptoms and prevent osteoporosis. It has estrogenic, progestogenic, and androgenic properties. Tibolone is approved and widely used in several countries, although not in the United States.

Pharmacokinetics

Pharmacokinetic parameters reported in healthy postmenopausal women.

References

1. Zuo, M, et al., & Duan, GL (2005). Stereoselectivity in metabolic 3-reduction of tibolone in healthy Chinese female volunteers. Acta pharmacologica Sinica 26(12) 1527–1530. DOI:10.1111/j.1745-7254.2005.00228.x PUBMED:https://pubmed.ncbi.nlm.nih.gov/16297354

Revisions

• 06/2025 initial generated model