.Pharmacolibrary.Drugs.G_GenitoUrinarySystemAndSexHormones.G03D_Progestogens.G03DA02_Medroxyprogesterone.Medroxyprogesterone

Information

name:Medroxyprogesterone
ATC code:G03DA02
route:intramuscular
n-compartments1

Medroxyprogesterone is a synthetic progestin, a derivative of progesterone, used primarily for hormone replacement therapy, treatment of endometriosis, dysmenorrhea, and as a component of some contraceptive formulations. It is available in both oral and injectable forms. Medroxyprogesterone acetate (MPA) is the main clinically used form. This drug is approved and in current therapeutic use.

Pharmacokinetics

Pharmacokinetic parameters in healthy adult women following a single intramuscular dose of medroxyprogesterone acetate (Depo-Provera) 150 mg.

References

  1. Zhou, XF, et al., & Sang, GW (1998). Pharmacokinetics of medroxyprogesterone acetate after single and multiple injection of Cyclofem in Chinese women. Contraception 57(6) 405–411. DOI:10.1016/s0010-7824(98)00048-1 PUBMED:https://pubmed.ncbi.nlm.nih.gov/9693401

  2. Zahradnik, HP (1995). [Depot gestagens]. Archives of gynecology and obstetrics 257(1-4) 536–541. DOI:10.1007/BF02264884 PUBMED:https://pubmed.ncbi.nlm.nih.gov/8579439

  3. Longo, N, et al., & Sile, S (2014). Single-dose, subcutaneous recombinant phenylalanine ammonia lyase conjugated with polyethylene glycol in adult patients with phenylketonuria: an open-label, multicentre, phase 1 dose-escalation trial. Lancet (London, England) 384(9937) 37–44. DOI:10.1016/S0140-6736(13)61841-3 PUBMED:https://pubmed.ncbi.nlm.nih.gov/24743000

Revisions


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