.Pharmacolibrary.Drugs.G_GenitoUrinarySystemAndSexHormones.G03D_Progestogens.G03DC02_Norethisterone.Norethisterone

Information

Norethisterone is a synthetic progestogen (progestin) used primarily in hormonal contraception and in the treatment of menstrual disorders, endometriosis, and other gynecological conditions. It is approved and still widely used in various oral contraceptive formulations, and as a progestin-only therapy.

Pharmacokinetics

Pharmacokinetics reported for healthy adult women following a single 5 mg oral dose.

References

1. Shi, YE, et al., & Fotherby, K (1987). Pharmacokinetics of norethisterone in humans. Contraception 35(5) 465–475. DOI:10.1016/0010-7824(87)90083-7 PUBMED:https://pubmed.ncbi.nlm.nih.gov/3621943

2. Vose, CW, et al., & Serlin, MJ (1979). Bioavailability and pharmacokinetics of norethisterone in women after oral doses of ethynodiol diacetate. Contraception 19(2) 119–127. DOI:10.1016/s0010-7824(79)80024-4 PUBMED:https://pubmed.ncbi.nlm.nih.gov/428229

3. Kiriwat, O, & Fotherby, K (1983). Pharmacokinetics of oral contraceptive steroids after morning or evening administration. Contraception 27(2) 153–160. DOI:10.1016/0010-7824(83)90086-0 PUBMED:https://pubmed.ncbi.nlm.nih.gov/6851554

Revisions

• 06/2025 initial generated model