.Pharmacolibrary.Drugs.G_GenitoUrinarySystemAndSexHormones.G03F_ProgestogensAndEstrogensInCombination.G03FA14_DydrogesteroneAndEstroge.DydrogesteroneAndEstroge

Information

A fixed combination drug of dydrogesterone (a synthetic progestogen) and estrogen (commonly estradiol or estradiol valerate). This combination is used primarily in hormone replacement therapy (HRT) to treat symptoms associated with menopause and to reduce the risk of endometrial hyperplasia in women with an intact uterus. The product is approved and marketed in various countries for this purpose.

Pharmacokinetics

No published clinical pharmacokinetic studies specific to the fixed combination of dydrogesterone and estrogen (ATC code G03FA14) were identified. The following PK parameters are estimated based on known pharmacokinetics of oral dydrogesterone and estradiol in healthy adult women.

References

1. Neumann, K, et al., & Griesinger, G (2022). Dydrogesterone and 20α-dihydrodydrogesterone plasma levels on day of embryo transfer and clinical outcome in an anovulatory programmed frozen-thawed embryo transfer cycle: a prospective cohort study. Human reproduction (Oxford, England) 37(6) 1183–1193. DOI:10.1093/humrep/deac045 PUBMED:https://pubmed.ncbi.nlm.nih.gov/35323905

2. Christin-Maitre, S, et al., & Reginster, JY (2003). Pharmacodynamics of follicle stimulating hormone (FSH) in postmenopausal women during pulsed estrogen therapy: Evidence that FSH release and synthesis are controlled by distinct pathways. The Journal of clinical endocrinology and metabolism 88(11) 5405–5413. DOI:10.1210/jc.2003-030094 PUBMED:https://pubmed.ncbi.nlm.nih.gov/14602781

3. Cucinelli, F, et al., & Lanzone, A (1999). Differential effect of transdermal estrogen plus progestagen replacement therapy on insulin metabolism in postmenopausal women: relation to their insulinemic secretion. European journal of endocrinology 140(3) 215–223. DOI:10.1530/eje.0.1400215 PUBMED:https://pubmed.ncbi.nlm.nih.gov/10216516

Revisions

• 06/2025 initial generated model