.Pharmacolibrary.Drugs.G_GenitoUrinarySystemAndSexHormones.G03F_ProgestogensAndEstrogensInCombination.G03FB01_NorgestrelAndEstrogen.NorgestrelAndEstrogen

Information

name:NorgestrelAndEstrogen
ATC code:G03FB01
route:oral
n-compartments1

Norgestrel and estrogen (commonly as ethinylestradiol) is a combination hormonal contraceptive used for prevention of pregnancy. This combination was widely used in oral contraceptive pills. Norgestrel is a synthetic progestogen and ethinylestradiol is a synthetic estrogen. The combination is approved for use as an oral contraceptive in many countries.

Pharmacokinetics

Estimated pharmacokinetic parameters for healthy adult women using standard oral contraceptive doses. No direct published sources for 'norgestrel and estrogen' combined PK model were found; parameters are estimated based on published PK studies of individual components.

References

  1. Kuhnz, W (1990). Pharmacokinetics of the contraceptive steroids levonorgestrel and gestodene after single and multiple oral administration to women. American journal of obstetrics and gynecology 163(6 Pt 2) 2120–2127. DOI:10.1016/0002-9378(90)90551-h PUBMED:https://pubmed.ncbi.nlm.nih.gov/2124087

  2. Olsson, B, & Landgren, BM (2001). The effect of tolterodine on the pharmacokinetics and pharmacodynamics of a combination oral contraceptive containing ethinyl estradiol and levonorgestrel. Clinical therapeutics 23(11) 1876–1888. DOI:10.1016/s0149-2918(00)89083-9 PUBMED:https://pubmed.ncbi.nlm.nih.gov/11768839

  3. Anderson, MS, et al., & Iwamoto, M (2011). Effect of raltegravir on estradiol and norgestimate plasma pharmacokinetics following oral contraceptive administration in healthy women. British journal of clinical pharmacology 71(4) 616–620. DOI:10.1111/j.1365-2125.2010.03885.x PUBMED:https://pubmed.ncbi.nlm.nih.gov/21395656

Revisions


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