.Pharmacolibrary.Drugs.G_GenitoUrinarySystemAndSexHormones.G03F_ProgestogensAndEstrogensInCombination.G03FB09_LevonorgestrelAndEstroge.LevonorgestrelAndEstroge

Information

name:LevonorgestrelAndEstrogen
ATC code:G03FB09
route:oral
n-compartments1

Levonorgestrel and estrogen are used in combination as oral contraceptives for the prevention of pregnancy. The combination is widely used and approved for contraceptive purposes in many countries. Levonorgestrel is a synthetic progestogen, while estrogen (usually ethinylestradiol) is a synthetic estrogen component.

Pharmacokinetics

Pharmacokinetic parameters are estimated for a typical healthy adult non-pregnant female, population for oral combined hormonal contraceptive use. No direct reference describing full compartmental PK parameters for the specific combination with ATC code G03FB09 was found.

References

  1. Adedoyin, A, et al., & Iwamoto, M (2019). Effect of letermovir on levonorgestrel and ethinyl estradiol pharmacokinetics
. International journal of clinical pharmacology and therapeutics 57(9) 450–457. DOI:10.5414/CP203483 PUBMED:https://pubmed.ncbi.nlm.nih.gov/31232280

  2. Kanarkowski, R, et al., & Jusko, WJ (1988). Pharmacokinetics of single and multiple doses of ethinyl estradiol and levonorgestrel in relation to smoking. Clinical pharmacology and therapeutics 43(1) 23–31. DOI:10.1038/clpt.1988.7 PUBMED:https://pubmed.ncbi.nlm.nih.gov/3121231

  3. Kuhnz, W (1990). Pharmacokinetics of the contraceptive steroids levonorgestrel and gestodene after single and multiple oral administration to women. American journal of obstetrics and gynecology 163(6 Pt 2) 2120–2127. DOI:10.1016/0002-9378(90)90551-h PUBMED:https://pubmed.ncbi.nlm.nih.gov/2124087

Revisions


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