.Pharmacolibrary.Drugs.G_GenitoUrinarySystemAndSexHormones.G03F_ProgestogensAndEstrogensInCombination.G03FB12_NomegestrolAndEstrogen.NomegestrolAndEstrogen .Pharmacolibrary.Drugs.G_GenitoUrinarySystemAndSexHormones.G03F_ProgestogensAndEstrogensInCombination.G03FB12_NomegestrolAndEstrogen.NomegestrolAndEstrogen| name: | NomegestrolAndEstrogen |
| ATC code: | G03FB12 | route: | oral |
| n-compartments | 1 |
Nomegestrol acetate with estrogen (often estradiol) is a combined oral contraceptive used for female contraception. It provides hormonal regulation for suppression of ovulation and endometrial stabilization. This combination is approved and available in several countries for use as an oral contraceptive.
Estimated pharmacokinetic parameters for healthy adult women receiving oral nomegestrol acetate 2.5 mg and estradiol 1.5 mg combination. Parameters are estimated based on what is known from available individual drug data, as no published population pharmacokinetic model for the fixed combination has been located.
Post, TM, et al., & de Greef, R (2016). Prediction of nomegestrol acetate pharmacokinetics in healthy female adolescents and adults by whole-body physiology-based pharmacokinetic modelling and clinical validation. Contraception 93(2) 133–138. DOI:10.1016/j.contraception.2015.08.017 PUBMED:https://pubmed.ncbi.nlm.nih.gov/26365792