.Pharmacolibrary.Drugs.G_GenitoUrinarySystemAndSexHormones.G03X_OtherSexHormonesAndModulatorsOfTheGenitalSystem.G03XB51_MifepristoneCombinations.MifepristoneCombinations .Pharmacolibrary.Drugs.G_GenitoUrinarySystemAndSexHormones.G03X_OtherSexHormonesAndModulatorsOfTheGenitalSystem.G03XB51_MifepristoneCombinations.MifepristoneCombinations| name: | MifepristoneCombinations | |
| ATC code: | G03XB51 | route: | oral |
| compartments: | 2 | |
| dosage: | 200 | mg |
| volume of distribution: | 25 | L |
| clearance: | 2.1 | L/h |
| other parameters in model implementation | ||
Mifepristone is a synthetic steroid with potent antiprogestational and antiglucocorticoid activities, often used in combination with a prostaglandin analogue to terminate early pregnancy. The combination is referred by ATC code G03XB51. Mifepristone is currently approved for medical abortion in several countries.
Estimated pharmacokinetic parameters for a typical healthy adult female population after oral single dose, as no specific population PK model describing G03XB51 combinations was found in the literature.
He, CH, et al., & Fotherby, K (1989). Pharmacokinetic study of orally administered RU 486 in non-pregnant women. Contraception 40(4) 449–460. DOI:10.1016/0010-7824(89)90052-8 PUBMED:https://pubmed.ncbi.nlm.nih.gov/2582770