.Pharmacolibrary.Drugs.G_GenitoUrinarySystemAndSexHormones.G04B_Urologicals.G04BD04_Oxybutynin.Oxybutynin

Information

Oxybutynin is an antimuscarinic agent used primarily to treat symptoms of overactive bladder, such as urinary urgency, frequency, and urge incontinence. It works by relaxing the bladder smooth muscle. Oxybutynin is approved and widely used in clinical practice.

Pharmacokinetics

Pharmacokinetic parameters in healthy adult volunteers after a single oral dose (5 mg tablet).

References

1. Kretschmar, M, et al., & Taubert, M (2021). A Population Pharmacokinetic Model of (R)- and (S-) Oxybutynin and Its Active Metabolites After Oral and Intravesical Administration to Healthy Volunteers. Journal of clinical pharmacology 61(7) 961–971. DOI:10.1002/jcph.1809 PUBMED:https://pubmed.ncbi.nlm.nih.gov/33368382

2. Lukkari, E, et al., & Neuvonen, PJ (1998). The pharmacokinetics of oxybutynin is unaffected by gender and contraceptive steroids. European journal of clinical pharmacology 53(5) 351–354. DOI:10.1007/s002280050392 PUBMED:https://pubmed.ncbi.nlm.nih.gov/9516036

3. Ganguly, A, et al., & Tyagi, P (2023). Treating Lower Urinary Tract Symptoms in Older Adults: Intravesical Options. Drugs & aging 40(3) 241–261. DOI:10.1007/s40266-023-01009-5 PUBMED:https://pubmed.ncbi.nlm.nih.gov/36879156

Revisions

• 06/2025 initial generated model