.Pharmacolibrary.Drugs.G_GenitoUrinarySystemAndSexHormones.G04B_Urologicals.G04BD09_Trospium.Trospium

Information

Trospium is a quaternary ammonium antimuscarinic agent used in the treatment of overactive bladder with symptoms of urge incontinence, urgency, and urinary frequency. It acts as a muscarinic antagonist that inhibits involuntary contractions of the bladder. Trospium is approved and in current use for these indications.

Pharmacokinetics

Pharmacokinetic parameters reported in healthy adult volunteers (mixed sex, n=24), following a single oral dose under fasting conditions.

References

1. Doroshyenko, O, et al., & Fuhr, U (2005). Clinical pharmacokinetics of trospium chloride. Clinical pharmacokinetics 44(7) 701–720. DOI:10.2165/00003088-200544070-00003 PUBMED:https://pubmed.ncbi.nlm.nih.gov/15966754

2. Harnett, MD, et al., & Sandage, BW (2013). Study of the population pharmacokinetic characteristics of once-daily trospium chloride 60 mg extended-release capsules in patients with overactive bladder and in healthy subjects. Clinical drug investigation 33(2) 133–141. DOI:10.1007/s40261-012-0039-8 PUBMED:https://pubmed.ncbi.nlm.nih.gov/23203138

3. Ganguly, A, et al., & Tyagi, P (2023). Treating Lower Urinary Tract Symptoms in Older Adults: Intravesical Options. Drugs & aging 40(3) 241–261. DOI:10.1007/s40266-023-01009-5 PUBMED:https://pubmed.ncbi.nlm.nih.gov/36879156

Revisions

• 06/2025 initial generated model