.Pharmacolibrary.Drugs.G_GenitoUrinarySystemAndSexHormones.G04B_Urologicals.G04BE03_Sildenafil.Sildenafil

Information

name:Sildenafil
ATC code:G04BE03
route:oral
n-compartments2

Sildenafil is a selective inhibitor of phosphodiesterase type 5 (PDE5), used primarily for the treatment of erectile dysfunction and pulmonary arterial hypertension. It is an approved medication and widely used for these indications.

Pharmacokinetics

Pharmacokinetic parameters in healthy adult male volunteers after a single oral dose.

References

  1. Gonzalez, D, et al., & Hornik, CP (2019). Population pharmacokinetics of sildenafil in extremely premature infants. British journal of clinical pharmacology 85(12) 2824–2837. DOI:10.1111/bcp.14111 PUBMED:https://pubmed.ncbi.nlm.nih.gov/31475367

  2. Hornik, CP, et al., & Gonzalez, D (2018). Association between oral sildenafil dosing, predicted exposure, and systemic hypotension in hospitalised infants. Cardiology in the young 28(1) 85–92. DOI:10.1017/S1047951117001639 PUBMED:https://pubmed.ncbi.nlm.nih.gov/28784200

  3. Shimizu, H, et al., & Kondo, K (2021). Evaluation of Pharmacokinetics, Safety, and Drug-Drug Interactions of an Oral Suspension of Edaravone in Healthy Adults. Clinical pharmacology in drug development 10(10) 1174–1187. DOI:10.1002/cpdd.925 PUBMED:https://pubmed.ncbi.nlm.nih.gov/33704925

Revisions


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