.Pharmacolibrary.Drugs.G_GenitoUrinarySystemAndSexHormones.G04B_Urologicals.G04BE07_Apomorphine.Apomorphine

Information

name:Apomorphine
ATC code:G04BE07
route:subcutaneous
n-compartments2

Apomorphine is a non-ergoline dopamine agonist used primarily in the treatment of motor fluctuations ('off' episodes) in Parkinson's disease. It is administered as a rescue medication for rapid symptom relief. It is approved for subcutaneous use and is not typically administered orally due to extensive first-pass metabolism and very low oral bioavailability.

Pharmacokinetics

Pharmacokinetic parameters reported in healthy adult volunteers following subcutaneous administration.

References

  1. Agbo, F, et al., & Navia, B (2021). Population pharmacokinetic analysis of apomorphine sublingual film or subcutaneous apomorphine in healthy subjects and patients with Parkinson's disease. Clinical and translational science 14(4) 1464–1475. DOI:10.1111/cts.13008 PUBMED:https://pubmed.ncbi.nlm.nih.gov/33650272

  2. Neef, C, & van Laar, T (1999). Pharmacokinetic-pharmacodynamic relationships of apomorphine in patients with Parkinson's disease. Clinical pharmacokinetics 37(3) 257–271. DOI:10.2165/00003088-199937030-00004 PUBMED:https://pubmed.ncbi.nlm.nih.gov/10511920

  3. Briganti, A, et al., & Montorsi, F (2006). A comparative review of apomorphine formulations for erectile dysfunction : recommendations for use in the elderly. Drugs & aging 23(4) 309–319. DOI:10.2165/00002512-200623040-00004 PUBMED:https://pubmed.ncbi.nlm.nih.gov/16732690

Revisions


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