name: | MagnesiumHydroxide |
ATC code: | G04BX01 | route: | oral |
n-compartments | 1 |
Magnesium hydroxide is an inorganic compound used as an antacid to relieve indigestion, heartburn, or dyspepsia, and as a laxative for short-term treatment of constipation. It is available over the counter and is commonly known as 'milk of magnesia.' Magnesium hydroxide is widely used and considered safe for short-term use. The drug is approved and widely used today.
No specific pharmacokinetic models or parameters for magnesium hydroxide in humans are described in published literature. Magnesium from magnesium hydroxide is absorbed to a very limited extent (<15%) in the gastrointestinal tract, with the majority being excreted unchanged in feces.
Scott, G, et al., & Rordorf, C (2004). Lack of effect of omeprazole or of an aluminium hydroxide/magnesium hydroxide antacid on the pharmacokinetics of lumiracoxib. Clinical pharmacokinetics 43(5) 341–348. DOI:10.2165/00003088-200443050-00006 PUBMED:https://pubmed.ncbi.nlm.nih.gov/15080766
Smith, GW, & Correa, MT (2004). The effects of oral magnesium hydroxide administration on rumen fluid in cattle. Journal of veterinary internal medicine 18(1) 109–112. DOI:10.1892/0891-6640(2004)18<109:teoomh>2.0.co;2 PUBMED:https://pubmed.ncbi.nlm.nih.gov/14765740
Zhang, YF, et al., & Zhong, DF (2014). Effects of an Al(3+)- and Mg(2+)-containing antacid, ferrous sulfate, and calcium carbonate on the absorption of nemonoxacin (TG-873870) in healthy Chinese volunteers. Acta pharmacologica Sinica 35(12) 1586–1592. DOI:10.1038/aps.2014.95 PUBMED:https://pubmed.ncbi.nlm.nih.gov/25327812