.Pharmacolibrary.Drugs.G_GenitoUrinarySystemAndSexHormones.G04C_DrugsUsedInBenignProstaticHypertrophy.G04CA02_Tamsulosin.Tamsulosin

Information

Tamsulosin is an alpha-1 adrenergic receptor antagonist primarily used to treat the symptoms of benign prostatic hyperplasia (BPH) in men. It helps relax the muscles in the prostate and bladder neck, making it easier to urinate. Tamsulosin is approved and widely used today for this indication.

Pharmacokinetics

Pharmacokinetic parameters in healthy adult male volunteers receiving single oral dose of tamsulosin fasting.

References

1. Piñeyro-Garza, E, et al., & Delgado-Roche, L (2022). Bioequivalence Assessment of an Oral Fixed-Dose Formulation of Dutasteride-Tamsulosin 0.5 mg/0.4 mg: A Randomized, Single-Blind, Single-Dose, 2-Period Crossover Study in Mexican Population Under Fasted Conditions. Clinical pharmacology in drug development 11(3) 318–323. DOI:10.1002/cpdd.1011 PUBMED:https://pubmed.ncbi.nlm.nih.gov/34384000

2. Gao, CH, et al., & Zhou, Q (2014). Personalized therapeutics for levofloxacin: a focus on pharmacokinetic concerns. Therapeutics and clinical risk management 10 217–227. DOI:10.2147/TCRM.S59079 PUBMED:https://pubmed.ncbi.nlm.nih.gov/24707182

3. Zhong, M, et al., & Zhang, H (2023). Determination of tamsulosin in plasma of healthy Chinese male subjects by a novel and simple LC-MS/MS method and its application to pharmacokinetic studies. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 1229 123901–None. DOI:10.1016/j.jchromb.2023.123901 PUBMED:https://pubmed.ncbi.nlm.nih.gov/37820472

Revisions

• 06/2025 initial generated model