.Pharmacolibrary.Drugs.H_SystemicHormonalPreparationsExclSexHormonesAndInsulins.H01B_PosteriorPituitaryLobeHormones.H01BA02_Desmopressin.Desmopressin .Pharmacolibrary.Drugs.H_SystemicHormonalPreparationsExclSexHormonesAndInsulins.H01B_PosteriorPituitaryLobeHormones.H01BA02_Desmopressin.Desmopressin| name: | Desmopressin |
| ATC code: | H01BA02 | route: | intranasal |
| n-compartments | 1 |
Desmopressin is a synthetic analogue of the natural pituitary hormone vasopressin. It is primarily used in the treatment of diabetes insipidus, nocturnal enuresis, and certain bleeding disorders such as hemophilia A and von Willebrand's disease. The drug is approved and widely used today.
Pharmacokinetic parameters reported in healthy adult volunteers after intranasal administration.
Sharthkumar, A, et al., & Shapiro, A (2008). Biologic response to subcutaneous and intranasal therapy with desmopressin in a large Amish kindred with Type 2M von Willebrand disease. Haemophilia : the official journal of the World Federation of Hemophilia 14(3) 539–548. DOI:10.1111/j.1365-2516.2008.01666.x PUBMED:https://pubmed.ncbi.nlm.nih.gov/18312368
Schütte, LM, et al., & Mathôt, RAA (2018). Pharmacokinetic Modelling to Predict FVIII:C Response to Desmopressin and Its Reproducibility in Nonsevere Haemophilia A Patients. Thrombosis and haemostasis 118(4) 621–629. DOI:10.1160/TH17-06-0390 PUBMED:https://pubmed.ncbi.nlm.nih.gov/29458233
Joukhadar, C, et al., & Eichler, HG (2003). A replicate study design for testing bioequivalence: a case study on two desmopressin nasal spray preparations. European journal of clinical pharmacology 59(8-9) 631–636. DOI:10.1007/s00228-003-0682-3 PUBMED:https://pubmed.ncbi.nlm.nih.gov/14564429