.Pharmacolibrary.Drugs.H_SystemicHormonalPreparationsExclSexHormonesAndInsulins.H02A_CorticosteroidsForSystemicUsePlain.H02AA01_Aldosterone.Aldosterone

Information

name:Aldosterone
ATC code:H02AA01
route:intravenous
n-compartments1

Aldosterone is a mineralocorticoid hormone produced by the adrenal cortex that plays a central role in the regulation of blood pressure, sodium, and potassium balance. It is not used as an approved therapeutic drug clinically; rather, its analogs and antagonists are used in the treatment of conditions like hypertension and heart failure.

Pharmacokinetics

Estimated pharmacokinetic parameters based on limited human data, as clinical PK studies specifically administering exogenous aldosterone in humans are sparse.

References

  1. Suh, A, et al., & Rosa, RM (2004). Racial differences in potassium disposal. Kidney international 66(3) 1076–1081. DOI:10.1111/j.1523-1755.2004.00857.x PUBMED:https://pubmed.ncbi.nlm.nih.gov/15327401

  2. Li, Y, et al., & Yu, Y (2016). Sodium Infusion Test for Diagnosis of Primary Aldosteronism in Chinese Population. The Journal of clinical endocrinology and metabolism 101(1) 89–95. DOI:10.1210/jc.2015-2840 PUBMED:https://pubmed.ncbi.nlm.nih.gov/26565948

  3. Meijers, WC, et al., & de Boer, RA (2014). Renal handling of galectin-3 in the general population, chronic heart failure, and hemodialysis. Journal of the American Heart Association 3(5) e000962–None. DOI:10.1161/JAHA.114.000962 PUBMED:https://pubmed.ncbi.nlm.nih.gov/25237044

Revisions


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