.Pharmacolibrary.Drugs.H_SystemicHormonalPreparationsExclSexHormonesAndInsulins.H02A_CorticosteroidsForSystemicUsePlain.H02AA02_Fludrocortisone.Fludrocortisone

Information

name:Fludrocortisone
ATC code:H02AA02
route:oral
n-compartments1

Fludrocortisone is a synthetic corticosteroid with potent mineralocorticoid properties, primarily used in the treatment of adrenocortical insufficiency (Addison's disease) and orthostatic hypotension. It is approved and in clinical use today.

Pharmacokinetics

Pharmacokinetic parameters reported for healthy adult volunteers following single oral dose.

References

  1. Polito, A, et al., & Alvarez, JC (2016). Pharmacokinetics of oral fludrocortisone in septic shock. British journal of clinical pharmacology 82(6) 1509–1516. DOI:10.1111/bcp.13065 PUBMED:https://pubmed.ncbi.nlm.nih.gov/27416887

  2. Hamitouche, N, et al., & Laviolle, B (2017). Population Pharmacokinetic-Pharmacodynamic Model of Oral Fludrocortisone and Intravenous Hydrocortisone in Healthy Volunteers. The AAPS journal 19(3) 727–735. DOI:10.1208/s12248-016-0041-9 PUBMED:https://pubmed.ncbi.nlm.nih.gov/28083797

Revisions

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