.Pharmacolibrary.Drugs.H_SystemicHormonalPreparationsExclSexHormonesAndInsulins.H02A_CorticosteroidsForSystemicUsePlain.H02AB02_Dexamethasone.Dexamethasone

Information

Dexamethasone is a synthetic corticosteroid with potent anti-inflammatory and immunosuppressant properties. It is used in the treatment of a variety of conditions, including autoimmune disorders, allergies, certain cancers, cerebral edema, and is commonly employed in the management of severe COVID-19 and as adjunctive therapy in chemotherapy-induced nausea. Dexamethasone is an approved drug and remains in clinical use.

Pharmacokinetics

Pharmacokinetic parameters reported for healthy adult subjects after a single 4 mg oral dose of dexamethasone.

References

1. Wen, J, et al., & Gonzalez, D (2024). Pharmacokinetics of Dexamethasone in Children and Adolescents with Obesity. Journal of clinical pharmacology 64(12) 1491–1504. DOI:10.1002/jcph.6108 PUBMED:https://pubmed.ncbi.nlm.nih.gov/39120865

2. Wang, X, et al., & Kansra, V (2019). Population Pharmacokinetics of Rolapitant in Patients With Chemotherapy-Induced Nausea and Vomiting. Clinical pharmacology in drug development 8(7) 850–860. DOI:10.1002/cpdd.733 PUBMED:https://pubmed.ncbi.nlm.nih.gov/31418538

3. Nakade, S, et al., & Miyata, Y (2008). Population pharmacokinetics of aprepitant and dexamethasone in the prevention of chemotherapy-induced nausea and vomiting. Cancer chemotherapy and pharmacology 63(1) 75–83. DOI:10.1007/s00280-008-0713-y PUBMED:https://pubmed.ncbi.nlm.nih.gov/18317761

Revisions

• 06/2025 initial generated model