.Pharmacolibrary.Drugs.H_SystemicHormonalPreparationsExclSexHormonesAndInsulins.H02A_CorticosteroidsForSystemicUsePlain.H02AB02_Dexamethasone.Dexamethasone_1

Information

Dexamethasone is a synthetic corticosteroid with potent anti-inflammatory and immunosuppressant properties. It is used in the treatment of a variety of conditions, including autoimmune disorders, allergies, certain cancers, cerebral edema, and is commonly employed in the management of severe COVID-19 and as adjunctive therapy in chemotherapy-induced nausea. Dexamethasone is an approved drug and remains in clinical use.

Pharmacokinetics

Pharmacokinetic parameters for intravenous administration of dexamethasone in healthy adult volunteers.

References

1. Li, L, et al., & Endeman, H (2023). Population pharmacokinetics of dexamethasone in critically ill COVID-19 patients: Does inflammation play a role?. Journal of critical care 78 154395–None. DOI:10.1016/j.jcrc.2023.154395 PUBMED:https://pubmed.ncbi.nlm.nih.gov/37542750

2. Guthrie, S (1991). The impact of dexamethasone pharmacokinetics on the DST: a review. Psychopharmacology bulletin 27(4) 565–576. PUBMED:https://pubmed.ncbi.nlm.nih.gov/1813902

3. Nijstad, AL, et al., & Zwaan, CM (2022). Overestimation of the effect of (fos)aprepitant on intravenous dexamethasone pharmacokinetics requires adaptation of the guidelines for children with chemotherapy-induced nausea and vomiting. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 30(12) 9991–9999. DOI:10.1007/s00520-022-07423-6 PUBMED:https://pubmed.ncbi.nlm.nih.gov/36287279

Revisions

• 06/2025 initial generated model