.Pharmacolibrary.Drugs.H_SystemicHormonalPreparationsExclSexHormonesAndInsulins.H02A_CorticosteroidsForSystemicUsePlain.H02AB09_Hydrocortisone.Hydrocortisone_1

Information

Hydrocortisone is a glucocorticoid hormone used as an anti-inflammatory and immunosuppressant agent. It is a synthetic form of cortisol and is widely used in the treatment of adrenal insufficiency (such as Addison's disease), severe allergies, asthma, and rheumatoid arthritis. Hydrocortisone is approved and commonly used in clinical practice both as oral and intravenous formulations.

Pharmacokinetics

Pharmacokinetic parameters for healthy adults after a single intravenous bolus dose.

References

1. Hamitouche, N, et al., & Laviolle, B (2017). Population Pharmacokinetic-Pharmacodynamic Model of Oral Fludrocortisone and Intravenous Hydrocortisone in Healthy Volunteers. The AAPS journal 19(3) 727–735. DOI:10.1208/s12248-016-0041-9 PUBMED:https://pubmed.ncbi.nlm.nih.gov/28083797

2. Vincze, I, et al., & Kopitkó, C (2022). Assessment of Antibiotic Pharmacokinetics, Molecular Biomarkers and Clinical Status in Critically Ill Adults Diagnosed with Community-Acquired Pneumonia and Receiving Intravenous Piperacillin/Tazobactam and Hydrocortisone over the First Five Days of Intensive Care: An Observational Study (STROBE Compliant). Journal of clinical medicine 11(14) –. DOI:10.3390/jcm11144140 PUBMED:https://pubmed.ncbi.nlm.nih.gov/35887904

3. Knych, HK, et al., & Kass, PH (2019). Pharmacokinetics of intravenous flumetasone and effects on plasma hydrocortisone concentrations and inflammatory mediators in the horse. Equine veterinary journal 51(2) 238–245. DOI:10.1111/evj.13002 PUBMED:https://pubmed.ncbi.nlm.nih.gov/30080272

Revisions

• 06/2025 initial generated model