.Pharmacolibrary.Drugs.H_SystemicHormonalPreparationsExclSexHormonesAndInsulins.H03A_ThyroidPreparations.H03AA01_LevothyroxineSodium.LevothyroxineSodium

Information

Levothyroxine sodium is a synthetic form of the thyroid hormone thyroxine (T4), used primarily for the treatment of hypothyroidism and as replacement therapy in patients with thyroid hormone deficiency. It is an FDA-approved medication and widely used today.

Pharmacokinetics

Pharmacokinetics in healthy adult volunteers after oral administration of a single dose; both sexes, fasting condition.

References

1. Fitch, R, et al., & Harper, D (2025). Phase 1 Study Evaluating the Pharmacokinetics, Dose Proportionality, Bioavailability, and Tolerability of Subcutaneous Levothyroxine Sodium (XP-8121). Clinical and translational science 18(5) e70244–None. DOI:10.1111/cts.70244 PUBMED:https://pubmed.ncbi.nlm.nih.gov/40348586

2. Mateo, RCI, & Hennessey, JV (2019). Thyroxine and treatment of hypothyroidism: seven decades of experience. Endocrine 66(1) 10–17. DOI:10.1007/s12020-019-02006-8 PUBMED:https://pubmed.ncbi.nlm.nih.gov/31321670

3. Yannovits, N, et al., & Benakis, A (2006). A bioequivalence study of levothyroxine tablets versus an oral levothyroxine solution in healthy volunteers. European journal of drug metabolism and pharmacokinetics 31(2) 73–78. DOI:10.1007/BF03191122 PUBMED:https://pubmed.ncbi.nlm.nih.gov/16898074

Revisions

• 06/2025 initial generated model