.Pharmacolibrary.Drugs.J_AntiinfectivesForSystemicUse.J01A_Tetracyclines.J01AA07_Tetracycline.Tetracycline

Information

Tetracycline is a broad-spectrum antibiotic belonging to the tetracycline class, historically used to treat various bacterial infections such as respiratory tract infections, urinary tract infections, skin infections, and some sexually transmitted infections. While widely used in the past, resistance and newer agents have limited its routine use in some countries, but it remains approved and is still used in specific indications.

Pharmacokinetics

Pharmacokinetics reported in healthy adult volunteers (oral administration).

References

1. Tao, RE, et al., & Feldman, SR (2023). Oral Tetracycline-Class Drugs in Dermatology: Impact of Food Intake on Absorption and Efficacy. Antibiotics (Basel, Switzerland) 12(7) –. DOI:10.3390/antibiotics12071152 PUBMED:https://pubmed.ncbi.nlm.nih.gov/37508248

2. Thompson, EJ, et al., & Hornik, CP (2019). Population Pharmacokinetics of Doxycycline in Children. Antimicrobial agents and chemotherapy 63(12) –. DOI:10.1128/AAC.01508-19 PUBMED:https://pubmed.ncbi.nlm.nih.gov/31548185

3. Rodvold, KA, et al., & Pai, MP (2020). Omadacycline: A Review of the Clinical Pharmacokinetics and Pharmacodynamics. Clinical pharmacokinetics 59(4) 409–425. DOI:10.1007/s40262-019-00843-4 PUBMED:https://pubmed.ncbi.nlm.nih.gov/31773505

Revisions

• 06/2025 initial generated model