.Pharmacolibrary.Drugs.J_AntiinfectivesForSystemicUse.J01A_Tetracyclines.J01AA08_Minocycline.Minocycline

Information

Minocycline is a second-generation tetracycline antibiotic used to treat various bacterial infections, including acne, respiratory tract infections, and sexually transmitted diseases. It is active against a broad spectrum of gram-positive and gram-negative organisms. Minocycline is approved and commonly used in clinical practice today.

Pharmacokinetics

Pharmacokinetic parameters reported for healthy adult volunteers after oral administration.

References

1. Pardos, SL, et al., & MacGowan, AP (2024). Population pharmacokinetics/pharmacodynamics of minocycline plus rifampicin in patients with complicated skin and skin structure infections caused by MRSA. The Journal of antimicrobial chemotherapy 79(12) 3303–3312. DOI:10.1093/jac/dkae363 PUBMED:https://pubmed.ncbi.nlm.nih.gov/39412246

2. Hnot, ML, et al., & Papich, MG (2015). Effect of feeding on the pharmacokinetics of oral minocycline in healthy research dogs. Veterinary dermatology 26(6) 399–e93. DOI:10.1111/vde.12246 PUBMED:https://pubmed.ncbi.nlm.nih.gov/26283447

3. Athanassa, Z, et al., & Tsakris, A (2025). Population pharmacokinetic model of oral minocycline in critically ill adult patients with ventilator-associated pneumonia. The Journal of antimicrobial chemotherapy 80(5) 1420–1426. DOI:10.1093/jac/dkaf090 PUBMED:https://pubmed.ncbi.nlm.nih.gov/40132622

Revisions

• 06/2025 Tomas Kulhanek, generated model from data extracted from PUBMED, DrugBank and LLM(GPT4.1)