.Pharmacolibrary.Drugs.J_AntiinfectivesForSystemicUse.J01B_Amphenicols.J01BA01_Chloramphenicol.Chloramphenicol_1

Information

name:Chloramphenicol_1
ATC code:J01BA01_1
route:oral
n-compartments1

Chloramphenicol is a broad-spectrum antibiotic originally discovered in 1947, used for the treatment of serious infections such as typhoid fever and bacterial meningitis. Due to its risk of serious side effects (most notably aplastic anemia), it is now rarely used in developed countries except in specific cases. It is still used in some regions for certain infections and is available in both oral and intravenous formulations.

Pharmacokinetics

Pharmacokinetics reported in healthy adults following oral administration of chloramphenicol base; parameters represent typical literature values.

References

  1. Sullins, AK, & Abdel-Rahman, SM (2013). Pharmacokinetics of antibacterial agents in the CSF of children and adolescents. Paediatric drugs 15(2) 93–117. DOI:10.1007/s40272-013-0017-5 PUBMED:https://pubmed.ncbi.nlm.nih.gov/23529866

  2. Zayyad, H, et al., & Paul, M (2017). Revival of old antibiotics: needs, the state of evidence and expectations. International journal of antimicrobial agents 49(5) 536–541. DOI:10.1016/j.ijantimicag.2016.11.021 PUBMED:https://pubmed.ncbi.nlm.nih.gov/28162982

  3. Lugo Goytia, G, et al., & Mejía, CL (2000). Relationship between clinical and biologic variables and chloramphenicol pharmacokinetic parameters in pediatric patients with sepsis. The Annals of pharmacotherapy 34(3) 393–397. DOI:10.1345/aph.19050 PUBMED:https://pubmed.ncbi.nlm.nih.gov/10917389

Revisions


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