.Pharmacolibrary.Drugs.J_AntiinfectivesForSystemicUse.J01C_BetaLactamAntibacterialsPenicillins.J01CA01_Ampicillin.Ampicillin_1

Information

Ampicillin is a broad-spectrum beta-lactam antibiotic of the penicillin class used to treat or prevent a wide variety of bacterial infections, including those of the respiratory tract, urinary tract, gastrointestinal tract, meningitis, septicemia, and endocarditis. Approved and widely used today, it is generally administered orally or by injection.

Pharmacokinetics

Pharmacokinetics reported in healthy adults after intravenous administration.

References

1. Setiawan, E, et al., & Roberts, JA (2023). Population Pharmacokinetics and Dosing Simulations of Ampicillin and Sulbactam in Hospitalised Adult Patients. Clinical pharmacokinetics 62(4) 573–586. DOI:10.1007/s40262-023-01219-5 PUBMED:https://pubmed.ncbi.nlm.nih.gov/36853585

2. Santavy, P, et al., & Urbanek, K (2023). Population pharmacokinetics of three alternative prophylactic antibiotics during cardiac surgery with extracorporeal circulation. Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia 167(2) 208–211. DOI:10.5507/bp.2022.033 PUBMED:https://pubmed.ncbi.nlm.nih.gov/35775358

3. Sullins, AK, & Abdel-Rahman, SM (2013). Pharmacokinetics of antibacterial agents in the CSF of children and adolescents. Paediatric drugs 15(2) 93–117. DOI:10.1007/s40272-013-0017-5 PUBMED:https://pubmed.ncbi.nlm.nih.gov/23529866

Revisions

• 06/2025 initial generated model