.Pharmacolibrary.Drugs.J_AntiinfectivesForSystemicUse.J01C_BetaLactamAntibacterialsPenicillins.J01CA04_Amoxicillin.Amoxicillin_1

Information

Amoxicillin is a broad-spectrum, beta-lactam antibiotic from the aminopenicillin class, used to treat a variety of bacterial infections such as respiratory tract infections, urinary tract infections, and otitis media. It is commonly used today and approved for clinical use in many countries.

Pharmacokinetics

Pharmacokinetic parameters reported for healthy adult subjects after intravenous administration (500 mg over 0.5 h).

References

1. Keij, FM, et al., & Flint, RB (2023). Oral and Intravenous Amoxicillin Dosing Recommendations in Neonates: A Pooled Population Pharmacokinetic Study. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 77(11) 1595–1603. DOI:10.1093/cid/ciad432 PUBMED:https://pubmed.ncbi.nlm.nih.gov/37757471

2. Vegas Cómitre, MD, et al., & Pelligand, L (2021). Population Pharmacokinetics of Intravenous Amoxicillin Combined With Clavulanic Acid in Healthy and Critically Ill Dogs. Frontiers in veterinary science 8 770202–None. DOI:10.3389/fvets.2021.770202 PUBMED:https://pubmed.ncbi.nlm.nih.gov/34869739

3. Wu, YE, et al., & Zhao, W (2021). Population Pharmacokinetics and Dosing Optimization of Amoxicillin in Chinese Infants. Journal of clinical pharmacology 61(4) 538–546. DOI:10.1002/jcph.1752 PUBMED:https://pubmed.ncbi.nlm.nih.gov/32996155

Revisions

• 06/2025 initial generated model