.Pharmacolibrary.Drugs.J_AntiinfectivesForSystemicUse.J01C_BetaLactamAntibacterialsPenicillins.J01CA10_Mezlocillin.Mezlocillin

Information

Mezlocillin is a broad-spectrum, semisynthetic penicillin antibiotic used primarily for the treatment of serious infections caused by susceptible Gram-negative and Gram-positive organisms, including Pseudomonas aeruginosa. It was previously widely used in hospitalized patients, particularly for intra-abdominal, urinary tract, and lower respiratory tract infections but is now largely withdrawn from the market and not approved in most countries today.

Pharmacokinetics

Pharmacokinetic parameters reported in healthy adult volunteers after intravenous administration.

References

1. Okamoto, MP, et al., & Appleman, MD (1992). Tissue concentrations of cefepime in acute cholecystitis patients. Therapeutic drug monitoring 14(3) 220–225. DOI:10.1097/00007691-199206000-00008 PUBMED:https://pubmed.ncbi.nlm.nih.gov/1412608

Revisions

• 06/2025 initial generated model