.Pharmacolibrary.Drugs.J_AntiinfectivesForSystemicUse.J01C_BetaLactamAntibacterialsPenicillins.J01CA12_Piperacillin.Piperacillin

Information

Piperacillin is a broad-spectrum β-lactam antibiotic of the ureidopenicillin class. It is commonly used, often in combination with the β-lactamase inhibitor tazobactam, for the treatment of a wide variety of bacterial infections, including respiratory tract infections, urinary tract infections, gastrointestinal infections, and sepsis. Piperacillin is approved and widely used in clinical practice today, particularly in hospital settings.

Pharmacokinetics

Pharmacokinetic parameters reported for healthy adult subjects following intravenous administration.

References

1. Dhaese, SAM, et al., & De Waele, JJ (2018). Population pharmacokinetics of continuous infusion of piperacillin in critically ill patients. International journal of antimicrobial agents 51(4) 594–600. DOI:10.1016/j.ijantimicag.2017.12.015 PUBMED:https://pubmed.ncbi.nlm.nih.gov/29277531

2. Alobaid, AS, et al., & Roberts, JA (2017). Population Pharmacokinetics of Piperacillin in Nonobese, Obese, and Morbidly Obese Critically Ill Patients. Antimicrobial agents and chemotherapy 61(3) –. DOI:10.1128/AAC.01276-16 PUBMED:https://pubmed.ncbi.nlm.nih.gov/28052849

3. Chen, R, et al., & Wang, LY (2016). Population Pharmacokinetics and Pharmacodynamics of Piperacillin/Tazobactam in Patients with Nosocomial Infections. European journal of drug metabolism and pharmacokinetics 41(4) 363–372. DOI:10.1007/s13318-015-0276-3 PUBMED:https://pubmed.ncbi.nlm.nih.gov/25894901

Revisions

• 06/2025 initial generated model