.Pharmacolibrary.Drugs.J_AntiinfectivesForSystemicUse.J01C_BetaLactamAntibacterialsPenicillins.J01CE08_BenzathineBenzylpenicill.BenzathineBenzylpenicill .Pharmacolibrary.Drugs.J_AntiinfectivesForSystemicUse.J01C_BetaLactamAntibacterialsPenicillins.J01CE08_BenzathineBenzylpenicill.BenzathineBenzylpenicill| name: | BenzathineBenzylpenicillin |
| ATC code: | J01CE08 | route: | intramuscular |
| n-compartments | 1 |
Benzathine benzylpenicillin (also known as penicillin G benzathine) is a long-acting depot antibiotic in the penicillin class, primarily used for the treatment and prophylaxis of infections caused by susceptible bacteria, such as group A Streptococcus (including rheumatic fever prophylaxis) and syphilis. It is approved and still used in medicine, typically administered by deep intramuscular injection.
Pharmacokinetic parameters reported for healthy adult subjects after single intramuscular dose.
Kado, JH, et al., & Manning, L (2020). Subcutaneous administration of benzathine benzylpenicillin G has favourable pharmacokinetic characteristics for the prevention of rheumatic heart disease compared with intramuscular injection: a randomized, crossover, population pharmacokinetic study in healthy adult volunteers. The Journal of antimicrobial chemotherapy 75(10) 2951–2959. DOI:10.1093/jac/dkaa282 PUBMED:https://pubmed.ncbi.nlm.nih.gov/32696033
Hand, RM, et al., & Carapetis, J (2019). A population pharmacokinetic study of benzathine benzylpenicillin G administration in children and adolescents with rheumatic heart disease: new insights for improved secondary prophylaxis strategies. The Journal of antimicrobial chemotherapy 74(7) 1984–1991. DOI:10.1093/jac/dkz076 PUBMED:https://pubmed.ncbi.nlm.nih.gov/30989171