.Pharmacolibrary.Drugs.J_AntiinfectivesForSystemicUse.J01C_BetaLactamAntibacterialsPenicillins.J01CF02_Cloxacillin.Cloxacillin .Pharmacolibrary.Drugs.J_AntiinfectivesForSystemicUse.J01C_BetaLactamAntibacterialsPenicillins.J01CF02_Cloxacillin.Cloxacillin| name: | Cloxacillin | |
| ATC code: | J01CF02 | route: | intravenous |
| compartments: | 1 | |
| dosage: | 500 | mg |
| volume of distribution: | 11.7 | L |
| clearance: | 7.12 | L/h |
| other parameters in model implementation | ||
Cloxacillin is a beta-lactam antibiotic of the penicillinase-resistant penicillin class. It is mainly used for the treatment of infections caused by penicillinase-producing staphylococci, particularly skin, respiratory tract, bone, and joint infections. Cloxacillin is approved for clinical use and remains a recommended choice for staphylococcal infections in many guidelines.
Pharmacokinetic parameters of cloxacillin reported in healthy adult volunteers (mixed sexes).
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James, ME, et al., & Sasi, P (2024). Gentamicin concentration and acute kidney injury in term neonates treated for neonatal sepsis with gentamicin and ampicillin-cloxacillin combination. Antimicrobial agents and chemotherapy 68(6) e0149523–None. DOI:10.1128/aac.01495-23 PUBMED:https://pubmed.ncbi.nlm.nih.gov/38747600