.Pharmacolibrary.Drugs.J_AntiinfectivesForSystemicUse.J01C_BetaLactamAntibacterialsPenicillins.J01CF02_Cloxacillin.Cloxacillin_1

Information

name:Cloxacillin_1
ATC code:J01CF02_1
route:oral
n-compartments1

Cloxacillin is a beta-lactam antibiotic of the penicillinase-resistant penicillin class. It is mainly used for the treatment of infections caused by penicillinase-producing staphylococci, particularly skin, respiratory tract, bone, and joint infections. Cloxacillin is approved for clinical use and remains a recommended choice for staphylococcal infections in many guidelines.

Pharmacokinetics

Pharmacokinetic parameters of cloxacillin after oral administration in healthy adult volunteers (mixed sexes).

References

  1. Yin, OQ, et al., & Chow, MS (2009). Effect of multidrug resistance gene-1 (ABCB1) polymorphisms on the single-dose pharmacokinetics of cloxacillin in healthy adult Chinese men. Clinical therapeutics 31(5) 999–1006. DOI:10.1016/j.clinthera.2009.05.014 PUBMED:https://pubmed.ncbi.nlm.nih.gov/19539100

  2. Heimdahl, A, et al., & Nord, CE (1988). A micromethod for determination of antimicrobial agents in bone. Drugs under experimental and clinical research 14(10) 649–654. PUBMED:https://pubmed.ncbi.nlm.nih.gov/3246209

  3. Middleton, RS, & Sinha, HK (1979). Magnapen treatment of infections in the elderly. The Journal of international medical research 7(1) 52–56. DOI:10.1177/030006057900700108 PUBMED:https://pubmed.ncbi.nlm.nih.gov/421965

Revisions


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