.Pharmacolibrary.Drugs.J_AntiinfectivesForSystemicUse.J01C_BetaLactamAntibacterialsPenicillins.J01CF03_Meticillin.Meticillin .Pharmacolibrary.Drugs.J_AntiinfectivesForSystemicUse.J01C_BetaLactamAntibacterialsPenicillins.J01CF03_Meticillin.Meticillin| name: | Meticillin |
| ATC code: | J01CF03 | route: | intravenous |
| n-compartments | 1 |
Meticillin (also known as methicillin) is a narrow-spectrum beta-lactam antibiotic of the penicillin class, once used mainly to treat infections caused by Staphylococcus aureus. It was particularly important for identifying methicillin-resistant Staphylococcus aureus (MRSA). Due to toxicity (mainly nephrotoxicity) and the availability of safer antibiotics, meticillin is no longer used clinically today and has been discontinued in many countries.
Estimated pharmacokinetic parameters for healthy adult individuals, as there are no directly referenced publications with quantitative parameters for meticillin identified.
Barbour, AM, et al., & Derendorf, H (2014). Application of pharmacokinetic/pharmacodynamic modelling and simulation for the prediction of target attainment of ceftobiprole against meticillin-resistant Staphylococcus aureus using minimum inhibitory concentration and time-kill curve based approaches. International journal of antimicrobial agents 43(1) 60–67. DOI:10.1016/j.ijantimicag.2013.08.016 PUBMED:https://pubmed.ncbi.nlm.nih.gov/24183800