.Pharmacolibrary.Drugs.J_AntiinfectivesForSystemicUse.J01C_BetaLactamAntibacterialsPenicillins.J01CG02_Tazobactam.Tazobactam

Information

name:Tazobactam
ATC code:J01CG02
route:intravenous
n-compartments2

Tazobactam is a beta-lactamase inhibitor, commonly used in combination with beta-lactam antibiotics like piperacillin to extend their spectrum of activity against resistant bacterial pathogens. It is approved and widely used in clinical practice for the treatment of various infections caused by susceptible organisms.

Pharmacokinetics

Pharmacokinetic parameters reported for healthy adult subjects after single intravenous dose.

References

  1. Monogue, ML, et al., & Kuti, JL (2016). Population Pharmacokinetics and Safety of Ceftolozane-Tazobactam in Adult Cystic Fibrosis Patients Admitted with Acute Pulmonary Exacerbation. Antimicrobial agents and chemotherapy 60(11) 6578–6584. DOI:10.1128/AAC.01566-16 PUBMED:https://pubmed.ncbi.nlm.nih.gov/27550351

  2. Kakara, M, et al., & Rizk, ML (2019). Population pharmacokinetics of tazobactam/ceftolozane in Japanese patients with complicated urinary tract infection and complicated intra-abdominal infection. Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 25(3) 182–191. DOI:10.1016/j.jiac.2018.11.005 PUBMED:https://pubmed.ncbi.nlm.nih.gov/30528208

  3. Larson, KB, et al., & Rizk, ML (2019). Ceftolozane-Tazobactam Population Pharmacokinetics and Dose Selection for Further Clinical Evaluation in Pediatric Patients with Complicated Urinary Tract or Complicated Intra-abdominal Infections. Antimicrobial agents and chemotherapy 63(6) –. DOI:10.1128/AAC.02578-18 PUBMED:https://pubmed.ncbi.nlm.nih.gov/30962340

Revisions


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