name: | AmoxicillinAndClavulanicAcidCombination |
ATC code: | J01CR50 | route: | intravenous |
n-compartments | 2 |
A broad-spectrum penicillin antibiotic combined with a beta-lactamase inhibitor (clavulanic acid) to treat bacterial infections resistant to amoxicillin alone. Approved and widely used for respiratory, urinary, and skin infections.
Pharmacokinetic parameters reported for healthy adult volunteers, both sexes, aged 18-50 years after a single intravenous administration.
Vegas Cómitre, MD, et al., & Pelligand, L (2021). Population Pharmacokinetics of Intravenous Amoxicillin Combined With Clavulanic Acid in Healthy and Critically Ill Dogs. Frontiers in veterinary science 8 770202–None. DOI:10.3389/fvets.2021.770202 PUBMED:https://pubmed.ncbi.nlm.nih.gov/34869739
Carlier, M, et al., & Roberts, JA (2013). Population pharmacokinetics and dosing simulations of amoxicillin/clavulanic acid in critically ill patients. The Journal of antimicrobial chemotherapy 68(11) 2600–2608. DOI:10.1093/jac/dkt240 PUBMED:https://pubmed.ncbi.nlm.nih.gov/23800901
Schouwenburg, S, et al., & Preijers, T (2025). A Pooled Population Pharmacokinetic Study of Oral and Intravenous Administration of Clavulanic Acid in Neonates and Infants: Targeting Effective Beta-Lactamase Inhibition. Clinical pharmacology and therapeutics 117(1) 193–202. DOI:10.1002/cpt.3423 PUBMED:https://pubmed.ncbi.nlm.nih.gov/39205386