.Pharmacolibrary.Drugs.J_AntiinfectivesForSystemicUse.J01D_OtherBetaLactamAntibacterials.J01DC03_Cefamandole.Cefamandole .Pharmacolibrary.Drugs.J_AntiinfectivesForSystemicUse.J01D_OtherBetaLactamAntibacterials.J01DC03_Cefamandole.Cefamandole| name: | Cefamandole |
| ATC code: | J01DC03 | route: | intravenous |
| n-compartments | 1 |
Cefamandole is a second-generation cephalosporin antibiotic, formerly used for the treatment of bacterial infections such as respiratory tract infections, urinary tract infections, and skin and soft tissue infections. It has activity against a broad spectrum of Gram-positive and Gram-negative bacteria. Due to concerns regarding safety, including hypoprothrombinemia and disulfiram-like reactions, and availability of safer alternatives, cefamandole is rarely used or approved today.
Pharmacokinetics determined in healthy adult volunteers after single intravenous injection.
Heikkilä, HJ (1999). New models for pharmacokinetic data based on a generalized Weibull distribution. Journal of biopharmaceutical statistics 9(1) 89–107. DOI:10.1081/BIP-100101002 PUBMED:https://pubmed.ncbi.nlm.nih.gov/10091912