.Pharmacolibrary.Drugs.J_AntiinfectivesForSystemicUse.J01D_OtherBetaLactamAntibacterials.J01DC08_Loracarbef.Loracarbef

Information

name:Loracarbef
ATC code:J01DC08
route:oral
n-compartments1

Loracarbef is a second-generation oral carbacephem antibiotic formerly used for the treatment of a variety of bacterial infections, including respiratory tract infections, skin infections, and urinary tract infections. It is related to the cephalosporins, has broad-spectrum antibacterial activity, but was withdrawn from the US market and is no longer approved for use today.

Pharmacokinetics

Pharmacokinetic parameters reported in healthy adult volunteers following a single oral 400 mg dose.

References

  1. Kays, MB, et al., & Miles, DO (1999). In vitro activity and pharmacodynamics of oral beta-lactam antibiotics against Streptococcus pneumoniae from southeast Missouri. Pharmacotherapy 19(11) 1308–1314. DOI:10.1592/phco.19.16.1308.30869 PUBMED:https://pubmed.ncbi.nlm.nih.gov/10555936

  2. Jacobs, MR, et al., & Appelbaum, PC (1999). Susceptibilities of Streptococcus pneumoniae and Haemophilus influenzae to 10 oral antimicrobial agents based on pharmacodynamic parameters: 1997 U.S. Surveillance study. Antimicrobial agents and chemotherapy 43(8) 1901–1908. DOI:10.1128/AAC.43.8.1901 PUBMED:https://pubmed.ncbi.nlm.nih.gov/10428910

Revisions


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