.Pharmacolibrary.Drugs.J_AntiinfectivesForSystemicUse.J01D_OtherBetaLactamAntibacterials.J01DC09_Cefmetazole.Cefmetazole

Information

Cefmetazole is a second-generation cephamycin antibiotic used for the treatment of infections caused by susceptible Gram-positive and Gram-negative bacteria. It is used primarily in Japan and some Asian countries for respiratory, urinary, and intra-abdominal infections, but is not widely approved in the US or EU.

Pharmacokinetics

Pharmacokinetic parameters in healthy adult volunteers after single intravenous administration.

References

1. Komatsu, T, et al., & Atsuda, K (2022). Timing of re-dosing based on population pharmacokinetic-pharmacodynamics target attainment analysis of cefmetazole in subjects undergoing lower gastrointestinal surgery. Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 28(8) 1105–1111. DOI:10.1016/j.jiac.2022.03.024 PUBMED:https://pubmed.ncbi.nlm.nih.gov/35400549

2. Borin, MT, et al., & Smith, TC (1990). Pharmacokinetics and dose proportionality of cefmetazole in healthy young and elderly volunteers. Antimicrobial agents and chemotherapy 34(10) 1944–1948. DOI:10.1128/AAC.34.10.1944 PUBMED:https://pubmed.ncbi.nlm.nih.gov/2291659

3. Tomizawa, A, et al., & Atsuda, K (2017). Optimal dosage of cefmetazole for intraoperative antimicrobial prophylaxis in patients undergoing surgery for colorectal cancer. Journal of pharmaceutical health care and sciences 3 1–None. DOI:10.1186/s40780-016-0071-6 PUBMED:https://pubmed.ncbi.nlm.nih.gov/28074152

Revisions

• 06/2025 initial generated model