.Pharmacolibrary.Drugs.J_AntiinfectivesForSystemicUse.J01D_OtherBetaLactamAntibacterials.J01DC13_Cefbuperazone.Cefbuperazone

Information

Cefbuperazone is a second-generation cephalosporin antibiotic, structurally related to cefoperazone. It has a broad spectrum of activity against various Gram-positive and Gram-negative bacteria, and has primarily been used to treat respiratory, urinary, and biliary tract infections. Its use is largely limited to certain countries, mainly in East Asia, and is not widely approved or used in the United States or Europe today.

Pharmacokinetics

Estimated pharmacokinetic parameters for healthy adult individuals. No published clinical pharmacokinetic studies with detailed parameters are available in the scientific literature.

References

1. Liu, D, et al., & Ding, L (2016). Pharmacokinetic profile of cefbuperazone in healthy Chinese volunteers after single and multiple drip intravenous infusion by HPLC-MS/MS. Journal of pharmaceutical and biomedical analysis 129 28–33. DOI:10.1016/j.jpba.2016.06.029 PUBMED:https://pubmed.ncbi.nlm.nih.gov/27394175

Revisions

• 06/2025 initial generated model