.Pharmacolibrary.Drugs.J_AntiinfectivesForSystemicUse.J01D_OtherBetaLactamAntibacterials.J01DD04_Ceftriaxone.Ceftriaxone

Information

Ceftriaxone is a third-generation cephalosporin antibiotic with broad-spectrum activity against both gram-positive and gram-negative bacteria. It is widely used for the treatment of infections such as pneumonia, meningitis, gonorrhea, and sepsis. Ceftriaxone is approved for clinical use worldwide and is often administered intravenously or intramuscularly in both hospital and outpatient settings.

Pharmacokinetics

Pharmacokinetic parameters reported in healthy adult subjects after single intravenous administration.

References

1. Simon, N, et al., & Urien, S (2006). Population pharmacokinetics of ceftriaxone and pharmacodynamic considerations in haemodialysed patients. Clinical pharmacokinetics 45(5) 493–501. DOI:10.2165/00003088-200645050-00004 PUBMED:https://pubmed.ncbi.nlm.nih.gov/16640454

2. Boast, A, et al., & Gwee, A (2024). Population pharmacokinetic modeling of ceftriaxone in cerebrospinal fluid in children: should we be using once- or twice-daily dosing for meningitis?. Antimicrobial agents and chemotherapy 68(11) e0074724–None. DOI:10.1128/aac.00747-24 PUBMED:https://pubmed.ncbi.nlm.nih.gov/39377581

3. Sullins, AK, & Abdel-Rahman, SM (2013). Pharmacokinetics of antibacterial agents in the CSF of children and adolescents. Paediatric drugs 15(2) 93–117. DOI:10.1007/s40272-013-0017-5 PUBMED:https://pubmed.ncbi.nlm.nih.gov/23529866

Revisions

• 06/2025 initial generated model