.Pharmacolibrary.Drugs.J_AntiinfectivesForSystemicUse.J01D_OtherBetaLactamAntibacterials.J01DD04_Ceftriaxone.Ceftriaxone_1

Information

Ceftriaxone is a third-generation cephalosporin antibiotic with broad-spectrum activity against both gram-positive and gram-negative bacteria. It is widely used for the treatment of infections such as pneumonia, meningitis, gonorrhea, and sepsis. Ceftriaxone is approved for clinical use worldwide and is often administered intravenously or intramuscularly in both hospital and outpatient settings.

Pharmacokinetics

Pharmacokinetic parameters reported in healthy adult subjects after single intramuscular administration.

References

1. Unemo, M, et al., & Jacobsson, S (2024). Pharmacodynamic evaluation of ceftriaxone single-dose therapy (0.125-1 g) to eradicate ceftriaxone-susceptible and ceftriaxone-resistant Neisseria gonorrhoeae strains in a hollow fibre infection model for gonorrhoea. The Journal of antimicrobial chemotherapy 79(5) 1006–1013. DOI:10.1093/jac/dkae063 PUBMED:https://pubmed.ncbi.nlm.nih.gov/38497988

2. Zhou, HH, et al., & Sun, M (1985). Single-dose pharmacokinetics of ceftriaxone in healthy Chinese adults. Antimicrobial agents and chemotherapy 27(2) 192–196. DOI:10.1128/AAC.27.2.192 PUBMED:https://pubmed.ncbi.nlm.nih.gov/3985603

3. Khan, AM, et al., & Fuchs, GJ (2006). Extended-interval gentamicin administration in malnourished children. Journal of tropical pediatrics 52(3) 179–184. DOI:10.1093/tropej/fmi085 PUBMED:https://pubmed.ncbi.nlm.nih.gov/16126804

Revisions

• 06/2025 initial generated model