.Pharmacolibrary.Drugs.J_AntiinfectivesForSystemicUse.J01D_OtherBetaLactamAntibacterials.J01DD07_Ceftizoxime.Ceftizoxime

Information

Ceftizoxime is a third-generation cephalosporin antibiotic indicated for the treatment of a variety of bacterial infections including respiratory tract, urinary tract, skin and soft tissue infections. It was previously widely used but has been largely replaced by newer agents and is not commonly used today.

Pharmacokinetics

Pharmacokinetic parameters reported for healthy adult volunteers after single intravenous injection.

References

1. Karna, P, et al., & Gooch, WM (1993). Population pharmacokinetics of ceftizoxime in premature newborns. Developmental pharmacology and therapeutics 20(3-4) 135–143. DOI:10.1159/000457554 PUBMED:https://pubmed.ncbi.nlm.nih.gov/7828445

2. Facca, B, et al., & Triesenberg, S (1998). Population pharmacokinetics of ceftizoxime administered by continuous infusion in clinically ill adult patients. Antimicrobial agents and chemotherapy 42(7) 1783–1787. DOI:10.1128/AAC.42.7.1783 PUBMED:https://pubmed.ncbi.nlm.nih.gov/9661021

3. Blouin, RA, et al., & Stoeckel, K (1989). Pharmacokinetics of intravenous cefetamet (Ro 15-8074) and oral cefetamet pivoxil (Ro 15-8075) in young and elderly subjects. Antimicrobial agents and chemotherapy 33(3) 291–296. DOI:10.1128/AAC.33.3.291 PUBMED:https://pubmed.ncbi.nlm.nih.gov/2729925

Revisions

• 06/2025 initial generated model