.Pharmacolibrary.Drugs.J_AntiinfectivesForSystemicUse.J01D_OtherBetaLactamAntibacterials.J01DD62_CefoperazoneAndBetaLactamaseInhi.CefoperazoneAndBetaLactamaseInhi

Information

Cefoperazone is a third-generation cephalosporin antibiotic, often combined with beta-lactamase inhibitors (such as sulbactam or tazobactam) to broaden its spectrum against beta-lactamase-producing gram-negative bacteria. This combination is used for the treatment of moderate to severe infections including respiratory tract, urinary tract, intra-abdominal infections, and sepsis. It is approved and used clinically, mainly in hospital settings.

Pharmacokinetics

Pharmacokinetic parameters estimated for typical adult patients based on available data for cefoperazone with sulbactam. No direct PK publication found for the exact combination ATC J01DD62; parameters estimated from available literature on cefoperazone combinations.

References

1. Woźnica, R, et al., & Kurec, D (2010). [Cefoperazone/sulbactam in continuous infusion]. Anestezjologia intensywna terapia 42(2) 80–84. PUBMED:https://pubmed.ncbi.nlm.nih.gov/21413432

Revisions

• 06/2025 initial generated model